I've only been on the Afrin train for about 4 months or so, so hopefully I can get out fairly easy, but I have all the telltale symptoms. Reddit; Wechat; Abstract. This is partially due to the fact that prolonged use can cause nasal swelling that effectively prevents the product from working as intended as a nasal decongestant. I used it for several months a couple of years ago and it was pretty hard to quit. … If you use Afrin Nasal Spray (oxymetazoline (nasal)) on a regular basis, use a missed dose as soon as you think about it. I had experience with the one with oxymetazoline hcl, so I thought I would try phenylephrine. Afrin nasal spray, for example, is an over the counter product containing this oxymetazoline hcl compound. A. Nasal decongestant sprays like Afrin (oxymetazoline) have a clear warning: “Do not use for more than three days. The weird thing is that the only active ingredient is oxymetazoline, which is a steroid, not an amphetamine, so I question this person's doctor and withdrawal statement (other than congestion of course). I once tried to break the afrin … While Afrin can be very effective, it comes with quite a few side effects. Use only as directed. Yeah, I have. Afrin’s packaging—somewhat ineffectively—cautions against using the drug for more than a few days at a time. The first two nights were hell, but it got better. I still use afrin on occasion, but I'm more careful about not using it on consecutive days. It can cause temporary burning, stinging, dryness, runny nose, and sneezing. For nasal congestion due to colds and allergies, millions of Americans reach for an over-the-counter decongestant to clear a stuffy nose. This was the one with phenylephrine in it. Oxymetazoline hydrochloride is an agonist at A1 and A2 adrenergic receptors.This compound is primarily found in nasal decongestant products because it causes vasoconstriction of the nasal passage and thus allows proper airflow when nasal congestion occurs. Some read the warning label: "Do not use this product if you have heart disease, high blood pressure, thyroid disease, diabetes, or difficulty in urination due to enlargement of the prostate gland unless directed by a doctor." Use only as directed. Do not use 2 doses at the same time or extra doses. However, one of the main side effects is rebound congestion, also commonly referred to as nasal spray addiction. My doctor had to ween me off it with a prescription antihistamine. Today, I will use Afrin but I dilute it 1/4 Aftin to 3/4 water and put it in an old nose spray atomizer. Oxymetazoline nasal spray is not FDA approved for use in children less than 6 years; however, its safety and efficacy are widely accepted, and it is in widespread use in children prior to procedures that may lead to epistaxis. Here is what I did. I put about 20 drops on a plate and then microwaved it to evaporate it, then I scraped it up with a knife. Nasal sprays can relieve a congested nose or throat, but people can develop a dependence with some types. Oxymetazoline and xylometazoline are both used as nasal mucosa decongesting α‐adrenoceptor agonists during a common cold. Luckily, I still have a 100% success rate with continued afrin use at night. The good effect won't last as long and you need to use it again and sooner! I'm also an admitted afrin addict. I have 100% clarity all day long and my sinuses literally close off the second I hit the pillow. Find out more about the different types of nasal spray and how to use them safely. 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