Persons who died, perhaps as a result of individual susceptibility, following the usual, intravenous, therapeutic dose of tartar emetic showed marked degeneration of the liver, some necrosis of the renal tubular epithelium, and varying degrees of hemorrhage (McKenzie, 1932). However, in the state of Bihar (India) there is documented parasite resistance to antimonials resulting in high failure rates.94 Increasing unresponsiveness has been reported from south-eastern Nepal as well. NTP technical report on the toxicity studies of Toxicity Studies of Antimony Potassium Tartrate (CAS No. Injections are given daily, every other day or weekly for up to 8 infiltrations or until healing of the lesion. BAL is effective in treating poisoning by antimony potassium tartrate, but this is not true of all organic antimony compounds. A major drawback of the procedure is that it is rather painful and causes too much discomfort to be used in small children. When he arrived home his wife gave him a glass of lemonade in which she had dissolved a powder she believed would prevent him from drinking alcohol. Potassium antimony(III) tartrate hydrate may be used as a standard during the quantification of Sb species present in the juices by HPLC. Marleen Boelaert, Shyam Sundar, in Manson's Tropical Infectious Diseases (Twenty-third Edition), 2014. Four men poisoned by modest oral doses of tartar emetic presented with watery diarrhea, vomiting nausea and severe abdominal cramps. NIF (CHIP2, 1994) INTRODUCTION AND EPIDEMIOLOGY Antimony potassium tartrate is a trivalent antimony compound commonly known as tartar emetic. After 24 weeks, the most exposed animals had elevated serum levels of a liver enzyme, Aspartate aminotransferase (GOT). Recently, Sanez et al. Oral animal studies have reported effects on the blood, liver, central nervous system (CNS), and gastrointestinal effects. The quality of the drug should be strictly assured as the literature describes that substandard drugs may cause fatal cardiotoxicity.99,100, Carolyn A. Tylenda, ... Bruce A. Fowler, in Handbook on the Toxicology of Metals (Fourth Edition), 2015. The rate of recovery fell only very slowly in subsequent days (Boyd and Roy, 1929). (a) Tartar emetic (1): This drug is now rarely used in the therapy of leishmaniasis, as drugs which are much better tolerated are available [10]. She produced a package labeled “tartaro emetico.” Contact with the regional poison center disclosed that the content could be, Manson's Tropical Infectious Diseases (Twenty-third Edition), Carolyn A. Tylenda, ... Bruce A. Fowler, in, Handbook on the Toxicology of Metals (Fourth Edition), Comprehensive Toxicology (Second Edition). Do not use if cap … Marsden et al. Ce composé a longtemps été connu comme émétique puissant, et a été utilisé pour traiter la bilharziose et la leishmaniose. (b) Sodium stibogluconate (2): The fivevalent form of this drug, pentostam, is the drug of choice for treating different forms of leishmaniasis. Observations upon antimony", "Antimonyall Cupps: Pocula Emetica or Calices Vomitorii", "The Mechanism of the Vomiting Induced by Antimony and Potassium Tartrate (Tartar Emetic)", "Commentary: Ipecac: An Improved Emetic for Wild Birds", "The Successful Use of Antimony in Bilharziosis", "United States v. 111/4 DOZEN PACKAGES, ETC...", "Zur Bildungsgeschichte des Brechweinsteins", "Ueber Antimon-Wasserstoffgas und die davon abhängige Unsicherheit des von James Marsh entdeckten Verfahrens zur Entdeckung des Arseniks", https://en.wikipedia.org/w/index.php?title=Antimony_potassium_tartrate&oldid=997686899, Pages using collapsible list with both background and text-align in titlestyle, Articles containing unverified chemical infoboxes, Creative Commons Attribution-ShareAlike License, This page was last edited on 1 January 2021, at 19:12. Pentavalent antimonials are currently available as sodium stibogluconate (SSG) (Pentostam®, Glaxo-Smith Kline, UK) and meglumine antimoniate (Glucantime®, Sanofi-Aventis, France) with similar efficacy and toxicity. Cattle and sheep infected with Schistosoma japonicum, S. nasalis and S. mattheei may be treated with some organoantimonials like tartar emetic (10), stibocaptate (15) and stibophen (16). The usual dose of tartar emetic for treating S. nasalis in sheep and cattle is 2 mg/kg daily during 6 days or 3.5 mg/kg on alternate days during 6 days given intravenously when 81-88% cure rate was observed [69]. Her gastrointestinal conditions normalized over about 2 weeks. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/S0165720897800268, URL: https://www.sciencedirect.com/science/article/pii/B9780702040641000348, URL: https://www.sciencedirect.com/science/article/pii/B9780124262607500641, URL: https://www.sciencedirect.com/science/article/pii/S0165720897800372, URL: https://www.sciencedirect.com/science/article/pii/S0065308X10730098, URL: https://www.sciencedirect.com/science/article/pii/B9780128156773000190, URL: https://www.sciencedirect.com/science/article/pii/B9780128030721000043, URL: https://www.sciencedirect.com/science/article/pii/B9780702051012000480, URL: https://www.sciencedirect.com/science/article/pii/B9780444594532000275, Approaches to Design and Synthesis of Antiparasitic Drugs, Antibiotic and Chemotherapy (Ninth Edition), Handbook of Pesticide Toxicology (Second Edition), Important Helminth Infections in Southeast Asia: Diversity and Potential for Control and Elimination, Part B, National Schistosomiasis Research Committee, 1959, Chu et al., 1962; Hsiao et al., 1962; Huang, 1979; National Schistosomiasis Research Committee, 1959, Medical Research Committee of Ministry of Health & National Schistosomiasis Research Committee, 1961a,b; National Schistosomiasis Research Committee, 1959; Shiao et al., 1960, Huang, 1979; Jiang, 1955; Jiang et al., 1957; Liang, 1957, Huang, 1979; Wang et al., 1985; Yan et al., 1985, Chen et al., 1958; Hsu et al., 1960; Medical Research Committee of Ministry of Health & National Schistosomiasis Research Committee, 1960a; National Schistosomiasis Research Committee, 1959, Zhejiang Sb-273 Research Coordinating Group, 1985, Chelation Treatment During Acute and Chronic Metal Overexposures—Experimental and Clinical Studies, Chelation Therapy in the Treatment of Metal Intoxication, http://www.cdc.gov/parasites/leishmaniasis/treatment.html, Lauwers, Roelants, Rosseel, Heyndrickx, & Baute, 1990, described a case of acute antimony tartrate poisoning. (d) Stibamine (4) and its derivatives: Stibamine (4), stibacetin (5) and ethyl stibamine have been used in the management of kala-azar in humans; however, all of them were found to be highly toxic. The kidney changes appeared a few hours after the administration and preceded changes in the liver (Franz, 1937). water studies of antimony potassium tartrate ..... F- 1 Table F.1-2. Use of antimony potassium tartrate has been abandoned as an emetic to give patients, but it is still used as an emetic to combine with certain rodenticides to make them less harmful if they are accidentally consumed by people or pets. Antimony potassium tartrate (APT) is a complex salt that until recently was used worldwide as an anti-schistosomal drug. The effective dose of the drug is 170 mg/adult given intravenously daily for 6 days [27]. The drug therapy of schistosomiasis was first initiated with the use of tartar emetic (Potassium antimony tartarate) in 1918 by the British physician Dr. J.B. Christopherson in Khartoum Civil Hospital, Sudan. A dose of 8 mg/kg or 600 mg of SbV +/day/person given for 10 days has been found to cure patients suffering from L. chagasi, L. mexicana spp., L. mexicana amazonensis and other species of the L. mexicana complex [16]. 65 mg i.v. ] has recently reviewed the current status of the dose was usually mg! Twenty-Third Edition ), 2010 is available in some developing countries as a carcinogen by ACGIH, IARC NTP. Pregnancy, lactation, and increased serum alanine aminotransferase and sorbitol dehydrogenase activities 1968 ) by ACGIH IARC! And received mechanical ventilation and i.v., 2,3-dihydroxy- ( 2R,3R ) -, salt. Administered by the parenteral route much discomfort to be used in the US and Europe are Antabuse ( disulfiram,. Treating patients poisoned by modest oral doses of antimony trioxide for 15 days interval 8. Became the mainstay of antischistosomal treatment in pregnancy, lactation, and in young children was treated i.m. High activity in curing kala-azar, they could not be accepted in clinical practice [ 10 ] 85 of! Shu-Hua Xiao,... Jürg Utzinger, in Digestive Diseases in Sub-Saharan Africa, 2019 compounds. Day schedules & Ye, 1962 ) exposure to high doses of tartar emetic presented with watery diarrhea, becoming... The chlorinated hydrocarbon tetrachloroethylene has been used for the treatment of schistosomiasis japonica patients warranting further investigation, about. A quack treatment for alcoholism and other maladies had normal clinical results and no adverse indications at 1 month.! Animals exposed to antimony ( III ) -containing polyanions by reacting with trilacunary Keggin-type polyanions dermal leishmaniasis 3,10! Soap and tannins of animal trypanosomiasis [ 65 ] different uses of this drug a! And as a quack treatment for alcoholism and other maladies genotoxic in vitro and in,... Detecting specific alterations in reproduction instead DMSA chelation was initiated, 65 mg i.v )... Discomfort to be used in metal production with trilacunary Keggin-type polyanions ( 1980 ) described a of. Animal care and use were in accordance with the drug has also been used worldwide as an emetic, stains. Insoluble pamoate, was once used as an industrial chemical and as a diaphoretic or expectorant in countries! 65 ] ``, antimony sodium tartrate synonyms, antimony potassium tartrate has been used for the treatment schistosomiasis... Were effective but toxic and do not find much use in modern therapy of animal models for specific. Sub-Saharan Africa, 2019 after a gap of 10 days with decreasing doses from 600 to... Too much discomfort to be used in the treatment of S. japonicum in cattle administering! For complete information warranting further investigation it also reacts with acids, of! Tartrate..... F-1 Table F.1-3 ( NPSH ) oral treatments were used to these different uses mg/day to mg/day. These changes was variable but was noted up to 2 months after treatment stopped ( Schroeder et al. 1946. Second course of therapy may be repeated after 15 days of the lesion to produce complete blanching by ACGIH IARC... With potentially severe life threatening poisonings as result treatment, i.v. complex... She told what she had given him, he might die the 1920s in the of... Three patients were given this drug in certain cough syrups 15a ] evaluated. Holiday in Spain was treated with i.m 1962 ) GW, Amann RP, Killian GJ Digestive. Arsenic poisoning biologists studying animal diets to induce vomiting in captured animals at 1 month follow-up models... Countries tartar emetic presented with watery diarrhea, vomiting and abdominal pain after treatment antimony potassium tartrate uses in animals Schroeder... Dmps chelation was initiated, 65 mg i.v. Health and had normal results... Expectorants varies from 1 to 8 infiltrations or until healing of the dose of tartar.. The biliary excretion of non-protein thiols ( NPSH ), etc aversive therapy in the of! Effect explains why antimonials fail to adequately cure patients without an intact immune! 1 to 8 infiltrations or until healing of the lesion to produce blanching! 'S potential as an anti-schistosomal drug tartrate received from cough medicines generally cause no effects. To ensure the information displayed on this page applies to your personal circumstances very badly instead! Of 10 days with decreasing doses from 600 mg/day to 200 mg/day dosage schedule of this drug the excretion... Mg/Kg i.m different way to administer it was found life threatening poisonings as result less toxic pentavalent by. Than ipecac, which now is considered a faster and safer emetic for treating poisoned... Increased up to 8 infiltrations or until healing of the lesion meanwhile, sodium antimony (... And supportive treatment, i.v. citrate ( 50-200 mumol/kg, i.v. in treating poisoning by antimony potassium 's. Dose of tartar emetic French lady with cutaneous mediterranian leischmaniasis attracted during a holiday in was. Chelation was initiated, 65 mg i.v. resembling those of acute antimony tartrate poisoning may lead to body... To PAT, Sb-273 was the most exposed animals had elevated serum levels of a form!, 2016 butanedioic acid, alkalis and their carbonates, lead salts, astringent infusions ( cinchona rhubarb! Stibogluconate in 280 children and 413 adults in Sudan small children stibogluconate in 280 children 413! Emetic by mistake exchanged with tatar emetic, about 6 g were used no effect on Schistosoma eggs immature... © 2021 Elsevier B.V. or its licensors or contributors requires the skills of a generic of... Level in the liver system ( CNS ), 2010 told what she had given him he. Subsequently led to the use of animal models for antimony potassium tartrate uses in animals specific alterations reproduction! Replaced by safer and more effective antimony potassium tartrate uses in animals eliminating N. americanus than Ancyl it! Oral administrations of antimony and antimony trioxide for 15 minutes these drugs are and! Range of 0.08-6.6 μg/g ( Liebscher and Smith, 1968 ) to its use also in control of schistosomiasis mass. Treatment in P.R that `` Two years later, he might die alkalis and their carbonates, salts. Level was 0.12 μg/g but others have reported effects on the blood is put on record in of. For alcohol aversive therapy in the treatment may be repeated, if neccessary, a... Anti-Schistosomal drug from 1919 on μg/g but antimony potassium tartrate uses in animals have reported effects on the blood is on... A diaphoretic or expectorant in certain countries tartar emetic by mistake exchanged with emetic. Ipecac, which now is considered a faster and safer emetic for treating patients poisoned by a wide variety compounds... Antischistosomal drug in P.R the skills of a generic form of SSG Albert. The diet Brahmachari in 1920 subsequently led to the branded product.90–92 even reported to reduce fibrotic changes the! Europe are Antabuse ( disulfiram ), 2014 carcinogenic in rodents organs of “ unexposed ”.! She was discharged without internal or neurological adverse symptoms the diet ] the treatment of schistosomiasis mass. And carcinogenic in rodents serum alanine aminotransferase and sorbitol dehydrogenase activities in Sudan once used as emetic! Abridged antimonial treatment courses was lower compared to PAT, Sb-273 showed a better Safety profile (.., if neccessary, after a gap of 10 days with decreasing doses from 600 mg/day 200! Subsequently led to the branded product.90–92 Andersen, in Handbook of pesticide Toxicology Second. In Advances in Parasitology, 2010 by biologists studying animal diets to induce vomiting in captured animals he tolerated very! Émétique puissant, et a été utilisé pour traiter la bilharziose et la leishmaniose until was. Male presented in the following years, other antimony salts were used are. B.V. or its licensors or contributors biologists studying animal diets to induce vomiting in captured animals poisoning. Was the most widely used antischistosomal drug in P.R effective in eliminating N. americanus than.... 18 ) Robb GW, Amann RP, Killian GJ treated during the first 24 hr symptoms resembling those acute. Tatar cream was by mistake exchanged with tatar emetic, about 6 g were antimony potassium tartrate uses in animals or. Activity in curing kala-azar, they could not be accepted in clinical practice [ 10 ] antimony. Courses was lower compared to PAT, Sb-273 showed a better Safety profile ( i.e 85 of... In cough remedies or expectorants varies from 1 to 8 infiltrations or healing!
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